Mepresone

METHYLPREDNISOLONE

4 mg Tablet
16 mg Tablet

CORTICOSTEROID

Category:

Description

The Cathay Drug Co., Inc.

Formulation

MEPRESONE 4 mg

Each tablet contains:

Methyprednisolone 4 mg

MEPRESONE 16 mg

Each tablet contains:

Methylprednisolone 16 mg

Pharmacology

Methylprednisolone is a glucocorticoid, prednisolone derivative which has the same activity and use as the main compound.  Methylprednisolone has no sodium retention properties like other glucocorticoids.

Indications

For the treatment of conditions in which corticosteroid therapy is indicated except in adrenocortical-deficiency states where hydrocortisone with supplementary fludrocortisone is preferred.

Contraindications

  • Systemic fungal infections and known hypersensitivity to the drug
  • Long-term administration of this drug is contraindicated in patients with peptic ulcer, severe osteoporosis and patients with a history of psychosis and herpes
  • Patients who undergo immunization procedure

Dosage and Administration

Adults

Initial dosage of methylprednisolone may vary from 4-48 mg daily.  Single dose or multiple doses depend on the condition being treated.

Multiple sclerosis:

160 mg daily orally for 1 week, then 64 mg/two days for 1 month.

Children

Adrenocortical insufficiency

Oral 0.117 mg/kg body weight or 3.33 mg/m2/day of surface body wide in 3 or 4 divided doses.

Other indications

Oral 0.417-1.67 mg/kg body weight or 12.5-50 mg/m2/day of surface body wide/day in 3-4 divided doses.

Or as prescribed by a physician.

Adverse Effects

Adverse effects occur in prolonged use or in high doses eg, fluid and electrolyte disturbances, muscle weakness, impaired wound healing, increased blood pressure, posterior subcapsular cataracts, suppression of growth in children, adrenal insufficiency, cushing’s syndrome, osteoporosis and peptic ulcer.

Warnings and Precautions

  • Not recommended in pregnant women and nursing mother, except if clearly needed.  Infants born to mothers who have received substantial doses of corticosteroid during pregnancy should be carefully monitored for symptoms of adrenal insufficiency.
  • While on corticosteroid therapy, patients should not be vaccinated against smallpox or other immunization procedures especially on high doses because of possible hazards of neurological complications.
  • The drug is not recommended for infants and children because prolonged use of corticosteroid may suppress growth.
  • If corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivity, close supervision is necessary as reactivation of the disease may occur.
  • Corticosteroid effects may increase in patients with hypothyroidism or cirrhosis.
  • Corticosteroids should be used cautiously in patients with ocular herpes simplex for fear of corneal perforation.
  • Corticosteroids may mask symptoms of infection.
  • Prolonged use of corticosteroids may decrease resistance and inability to localize infections.

Drug Interactions 

  • It is recommended to administer concomitantly with food to minimize gastrointestinal irritation.
  • Administered concomitantly with other non-steroidal anti-inflammatory drugs or antirheumatic drugs may cause gastrointestinal hemorrhage.
  • When administered concomitantly with antidiabetic drugs, the dosage should be adjusted.
  • Patients who undergo smallpox vaccination or other immunization procedures especially at high doses.

Caution

Foods, Drugs, Devices and Cosmetics Act prohibits dispensing without prescription.

Storage

Store at temperatures not exceeding 30OC.  Protect from light.

Availability

Methylprednisolone (Mepresone) 4 mg Tablet:

Box of 10 blisters x 10 tablets

Methylprednsolone (Mepresone) 16 mg Tablet

Box of 5 strips x 6 tablets

KEEP OUT OF REACH OF CHILDREN

 

Manufactured by

PT DEXA MEDICA

Jl. Bambang Utoyo 138

Palembang, Indonesia

Imported and Distributed by

THE CATHAY DRUG CO., INC.

120 Amorsolo St.

Legaspi Village, Makati City

Philippines

 

 

 

 

Reviews

There are no reviews yet.

Be the first to review “Mepresone”

Your email address will not be published. Required fields are marked *

START TYPING AND PRESS ENTER TO SEARCH